Who wants to live to 150?

Researchers look to DNA for clues to extending human lifespans

In recent years, the quest to reverse ageing has transitioned from the realm of science fiction to tangible scientific inquiry, with prominent figures such as Professor David Sinclair at the forefront.

Sinclair, a genetics professor at Harvard Medical School, has dedicated his career to understanding the mechanisms of ageing and exploring potential interventions to decelerate or even reverse this process.

Central to Sinclair’s research is the concept that ageing results from the loss of epigenetic information — the instructions that dictate gene expression without altering the underlying DNA sequence.

He posits that this loss leads to cellular dysfunction and the manifestations of ageing.

In a 2023 study published in Cell, Sinclair and his team demonstrated that by restoring this epigenetic information, they could reverse signs of ageing in mice.

The study suggests that changes to DNA organisation and regulation, rather than alterations to the genetic code itself, can drive ageing, and that restoring this organisation can reverse these signs.

Beyond laboratory research, Sinclair practices lifestyle interventions aimed at promoting longevity. His personal regimen includes regular exercise, sauna sessions, ice baths, a predominantly plant-based diet and intermittent fasting. He also incorporates certain supplements into his diet.

These practices align with his belief that certain lifestyle choices can activate longevity pathways in our biology, potentially extending healthspan and lifespan.

Do you want to live forever?

Sinclair’s commitment to these interventions is reflected in his personal health metrics. At 55, his biological age is reportedly closer to 45, as measured by biomarkers analysed through platforms such as InsideTracker.

Sinclair envisions a future where age reversal becomes a practical reality for humans. He predicts that within a decade, advancements in medical science will enable us to control and even reverse biological ageing, potentially extending human lifespan to around 120 years.

He has even been quoted as saying that the first person to live to 150 has already been born.

This optimistic outlook is grounded in ongoing research and emerging technologies aimed at decoding and manipulating the biological processes underpinning ageing.

However, some scientists have criticised Sinclair for overstating the implications of his research findings, emphasising the need for rigorous validation and cautious interpretation of results.

Sinclair’s pioneering research offers a compelling glimpse into the possibilities of age reversal — but a lot more work needs to be done in this field before any of us can start making plans beyond current typical age spans.

References: Brisbane Times, Harvard, KED Global, WSJ

Disclaimer: This should not be taken as medical advice, and the information may not be suited to your individual circumstances. Always consult a registered professional before changing your health, fitness or medical regime.